In 1994, theJournal of Nutritional Biochemistrystated, "Disease states due to glutathione deficiency are not common.”
Well, 25 years and 90 thousand journal articles later we have found
this statement to be false on all levels. Glutathione is recognized as
an extremely important intracellular antioxidant that also plays a
central role in the detoxification and elimination of potential
carcinogens and toxins. Studies have found that glutathione synthesis
and tissue glutathione levels become significantly lower with age,
leading to decreased ability to respond to oxidative stress or toxin
The higher the glutathione peroxidasein the plasma or red blood cells, the more your body is running through and out of glutathione. Now consider the follow…
Total glutathione peroxidase activity was elevated in females 65
years of age or older. Cigarette smoking significantly elevated
glutathione peroxidase. Alcohol elevated glutathione peroxidase, with
the highest levels seen in drinkers who also smoked. Increased
glutathione peroxidase was also seen in vigorous exercise, especially
triathletes and marathoners.
According to the National Cancer Institute, dairy
products, cereals and breads are low in glutathione. Fruit and
vegetables have moderate to high amounts of glutathione. Frozen versus
fresh foods had similar amounts of glutathione. Processing and
preservation resulted in considerable loss of glutathione.
A 27% reduction in glutathionehas been reported in the cerebrospinal fluid of schizophrenic patients.
Studies have shown that dietary glutathione enhances the metabolic
clearance and reduces net absorption of dietary peroxidized lipids,
which cause intense cellular damage.
High altitude exposurereduces glutathione levels.
Glutathione functions as an antioxidant and can maintain vitamin C in its reduced and functional form.
Chronically low glutathione levelsare seen in premature infants,alcoholic cirrhotics and individuals with HIV.
Glutathione increases sperm motility patterns and sperm morphology.
In a double-blind, placebo-controlled crossover trial of infertile
patients, patients were randomly and blindly assigned to treatment with
one injection every other day of either glutathione at 600 mg or an
equal volume of placebo. All the glutathione selected patients showed
an increase in sperm concentration and a highly statistically
significant improvement in sperm motility, sperm kinetic parameters and
sperm morphology. Want to get pregnant? Make sure your husband has
optimal levels of glutathione.
From the journal of Digestion: Glutathione is
extremely important in normal functioning of the pancreas, being needed
for normal folding of the proteins that will ultimately form key
digestive enzymes when the pancreas is stimulated after a meal. In
patients with chronic pancreatitis, it has been found that glutathione
is often significantly depleted, suggesting that lack of glutathione has
a role in the generation and/or maintenance of the disease. In
addition, many patients suffering from chronic pancreatitis appear to be
under xenobiotic or oxidant stress, creating an evengreater need for glutathione.
Since the pancreas is under relative glutathione "stress” during the
normal process of packing and secreting digestive enzymes, it is easy to
see how the lack of glutathione could have a role in chronic
From the Journal of Brain Research Reviews:Glutathione depletioncan
enhance oxidative stress and may increase levels of excitotoxic (toxins
that excite neurons to the point of death) molecules, which may
initiate cell death in specific nerve cell populations. Evidence of
oxidative stress andreduced glutathione statusis found in Lou Gehrig’s disease, Parkinson’s disease and Alzheimer’s disease.
From the Annals of Pharmacotherapy:Glutathione is importantin
DNA synthesis and repair, protein and prostaglandin synthesis, amino
acid transport, metabolism of toxins and carcinogens, enhancement of
immune function, prevention of oxidative cell damage and enzyme
From the Journal Acta Dermato-Venereologica:Low levels of blood glutathionewere
found in patients with pemphigoid, acne conglobata, polymyositis,
rheumatoid arthritis, scleroderma, systemic lupus erythematosus, atopic
dermatitis, eczema and psoriasis.
From the Journal of the Federation of American Societies for Experimental Biology:Intracellular
glutathione enhances the immunologic function of lymphocytes (perhaps
the most important immune cell line in preventing infection and
cancer).Low levels of glutathionelimit the optimal
functioning of T cells. Cytotoxic T cell (necessary to eliminate
cancer) responses and interleukin-II-dependent functions are inhibited
even by a partialdepletion of the intracellular glutathionepool.
From the journal of Ocular Pharmacological Therapy:Susceptibility
of the lens nucleus to oxidative damage and loss of transparency has
been shown in experimental animal models, including exposure to
hyperbaric oxygen, x-ray and UVA light.Depletion of glutathioneallows the levels of oxidant to damage lens tissue and structure.
From the Journal of Laboratory and Clinical Science:An increased incidence oflow glutathione levelsin
apparently healthy subjects suggests a decreased capacity to maintain
metabolic and detoxification reactions that are stimulated by
glutathione. The authors stated thatglutathione status, physical health, and longevity are closely related.
From the Lancet: The plasma glutathione in young,
healthy adults was 0.54 umol/L; in healthy elderly it was 0.29 umol/L;
in elderly outpatients it was 0.24 umol/L; and in elderly inpatients it
was 0.17 umol/L. Aging results in a decrease in plasma glutathione and
an increase in oxidative damage in apparently healthy individuals.
Simply put, if you want young cells and the ability to overcome disease you need to work on getting your glutathione levels up!