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Curbing Inflammation May Reduce Heart Disease Risk

Posted By Administration, Monday, June 21, 2010
Updated: Friday, April 18, 2014

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by Zina Kroner, DO

It has been established in prior studies that if one has an inflammatory condition such as psoriasis, for example, the risk of heart disease increases substantially.  A pro-inflammatory agent called tumor necrosis factor (TNF) tends to be elevated in patients with many  inflammatory conditions such as psoriasis and rheumatoid arthritis.  Prior studies have shown us that when patients took medication that act again TNF, the risk of heart disease decreased (J Am Acad Dermatol 2005; 52:262).

A recent study in Norway looked at patients with 3 different inflammatory conditions: rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis.  Patients were treated with TNF antagonists and aortic stiffness was assessed as a marker of heart disease.  It was found that those receiving anti-TNF agents as compared to placebo had statistically significant decreases in aortic stiffness and C-reactive protein levels (a marker for heart diseaes).  Although the study was of small sample size and of short duration, it can be concluded that TNF-antagonists may potentially decrease heart disease risk. 

Medications that are TNF antagonists have a wide and potentially detrimental side effect profile and need to be prescribed judiciously. There are an array of natural treatments that can be catered to one's condition that can potentially lower TNF and cardio-CRP levels as well. 

This is an important study in that it substantiates the fact that decreasing inflammation in our bodies will help reduce cardiovascular risk.  This can be done via a number of fronts depending on one's unique inflammatory condition. 


Source: Angel K et al. Tumor necrosis factor-{alpha} antagonists improve aortic stiffness in patient with inflammatory arthropathies: A controlled study. Hypertension 2010 Feb; 55:333.

Tags:  heart disease  inflammation 

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